Emily Deschanel as Dr. Temperance "Bones" Brennan: a forensic anthropologist working at the renowned Jeffersonian Institute located in Washington, D.C. She is an empiricist and author of crime fiction based on her experiences.
David Boreanaz as Seeley Booth: Brennan aids FBI Special Agent
Seeley Booth in his investigations involving human remains that cannot
be identified without Brennan's skills in forensic anthropology. Booth
is often used to provide a layman's translation of the scientific
jargon-filled dialog.
Michaela Conlin as Angela Montenegro: a forensic artist at the Jeffersonian Institute and Dr. Brennan's best friend. Angela is Dr. Brennan's team specialist in craniofacial
reconstruction—helping to determine what their victims looked like
before death to help determine their identity—and can generate holograms
using her three-dimensional graphics program (The Angelator and later
The Angelatron) to simulate various virtual scenarios of a crime to help
determine cause of death.
T. J. Thyne as Dr. Jack Hodgins: an entomologist who is also an expert on spores and minerals but whose hobby is conspiracy theories.
He helps teach Zack how to be socially normal. His family is extremely
wealthy and are major sponsors of the Jeffersonian; Hodgins wishes for
this status to remain concealed from his bosses because he does not want
to be seen as a superior (it eventually came out during an
investigation, although nobody has allowed it to significantly impact
their relationships with him). In season five, he marries Angela
Montenegro, and she gives birth to their son in season six.
Eric Millegan as Dr. Zack Addy
(Seasons 1–3; guest star, seasons 4–5): introduced as Dr. Brennan's
graduate student and assistant at the Jeffersonian Institute at the
start of the series. In the second season, he receives his doctorate in
Forensic Anthropology and Mechanical Engineering and becomes a
professional forensic anthropologist.
Tamara Taylor as Dr. Camille Saroyan (Season 2–present): is the head of the Forensic Division at Jeffersonian Institute and a pathologist. She was born in The Bronx and was a coroner in New York City. At first, she and Dr. Brennan have an uneasy working relationship.
John Francis Daley as Dr. Lance Sweets (Season 3–present): a psychologist
assigned to Booth and Brennan after Booth arrests her father. He works
as a psychologist for the FBI and as a psychoanalyst for the team at the
Jeffersonian.
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